As part of a series of tributes to my father, Professor Edward J Duke (Head of the Department of Zoology UCD , 1979 to 2002) , who passed away last month, I’m putting up his first significant scientific publication here.
He achieved so much in his life, and science was only one small part of that.
Yet, this might be of interest to those who knew ‘Eamonn’ in his professional capacity as a scientist. It was published as part of the ‘Letters to Nature’ on the 9th January 1963, when he was just 23 years of age, and a doctoral student in Queen’s University Belfast.
Thank you to Kay Nolan and Tom Bolger, former UCD colleagues for finding this for me.
My doctor is an algorithm: ‘Medicine has always welcomed new technology’
With the advance of artificial intelligence, medical practises are being overtaken. Could the GP become a relic of a bygone age
April 13 2017 2:30 AM
‘Good afternoon, the AI will see you now.” This could be the future of family practice medicine as machines become better equipped to do many of the things that traditionally made up the GP’s job description.
Machines have always threatened human jobs, but up to the 21st century they were only a serious threat to repetitive, low-skilled jobs. Times have changed and the higher skilled jobs today are threatened by the advance of artificial intelligence (AI). In the past few years, intelligent machines have begun to perform complex tasks far better and quicker than intelligent, skilled humans.
The ‘good GP’ we know will always know his patients well; their medical history, their personality, details about their family and their foibles, and will retain this background information and call on it when assessing patients. The good GP would know, for example, that Mr Murphy is probably upset, rather than clinically depressed, because his father died last week and he has no depression history.
However, unlike the good GP, who may be overworked, and stressed by the demands of a busy clinic, computers with built-in AI have an almost unlimited capacity to store information in medical records, and to recognise patterns that may have been missed by the GP. They are also excellent at measuring things, such as blood pressure, and analysing results, such as a routine blood test.
In recent years, scientists working in AI made a breakthrough when they developed software based on the working of the human brain, rather than, as was the case before, sticking to a rigid rule book. This software could learn from the environment, making mistakes, and correcting them, like a child learns. The world saw its first artificial ‘self-learning systems’.
There were implications from this for the GP, and other professionals, as suddenly it wasn’t just the old story of machines replacing low-skilled workers; their jobs were on the line too. GPs faced the prospect of being confined to a decreasing number of areas where they are still superior to artificial rivals, or worse still, to become redundant; a charming medical relic of a bygone age.
The role of specialist medical consultants – not just GPs – is also coming under threat too from sophisticated ‘deep learning systems’ which are already outperforming doctors in specialised areas of medicine, says Professor Barry O’Sullivan, director of the Insight Centre for Data Analytics at the Department of Computer Science, in University College Cork, and a leading AI researcher.
“Dermatology is one such field,” he says. “A very recent paper that appeared in (research journal) Nature showed that a deep learning system could outperform human dermatologists at identifying skin cancer by quite a margin.”
Another area where AI is already better than doctors is radiology, adds O’Sullivan. A radiologist can recognise patterns in scans, based on years of experience. However, no matter how experienced the radiologist, he can’t store the amount of scans that AI can, while comparing them to a particular scan in order to assess, for example, the likelihood of a stroke or epilepsy. Meanwhile, there are further reasons for GPs not to be cheerful about the future with plans in the UK, supported by the NHS, to use smartphones to bypass the GP clinic altogether. A pilot scheme, run by private firm Babylon Health is encouraging people to consult a ‘chatbot’, equipped with AI, rather than a human being when they contact the 111 non-emergency line.
Patients key in symptoms, and AI determines how urgent each case is, and whether the user should be told to go straight to A&E, the chemist or simply go home to bed. The AI system makes decisions based on 300 million pieces of information, and the company says trials have shown the system is faster and more accurate than doctors. Certainly, most experts agree the future of medicine is ‘personalised medicine’, with disease treatments being tailored to suit personal needs. This is an area that AI excels, as it is very good at looking at medical data and finding specific treatments for patients which can, in some cases, even save their lives.
“For example, organisations such as Cancer Commons have assisted cancer patients survive conditions that were regarded as fatal in their situations by combining AI with extremely rich and individual-level data,” says Prof O’Sullivan. “The founder of Cancer Commons, Marty Tenenbaum, is one such survivor.”
Brendan Kelly, professor of psychiatry at Trinity College Dublin, says: “Computers and electronic diagnostic aids are delivering more and more information every year in medicine. And it is likely that computers and other devices, with their essentially infinite data storage and pattern recognition abilities, will continue to add increasing value to medical care.
He adds: “AI is especially useful in diagnosis: recognising skin lesions, monitoring measurable indices of body function, and identifying known patterns of symptoms and signs.
“It is less useful for other dimensions of medical care: contextualising findings in the context of the patient’s life, moving from recognising a pattern to agreeing a narrative between doctor and patient, and providing reassurance.
“AI is also less useful for picking up on the unexpected elements in a patient’s presentation: noting, for example, that a patient presenting with a lesion on his ear also has swollen ankles. Or noticing that someone with chest pain smells strongly of alcohol at 11 in the morning and might have an alcohol problem (which might or might not be related to the chest pain). Or noticing that a woman who comes to have a prescription renewed brings along her child, whom the nurse remembers has missed a vaccination, and can receive it today.”
Kelly isn’t worried about his job just yet though.
“Medicine has always welcomed new technologies and benefited hugely from them: stethoscopes, x-ray machines, MRI. But these tools amplify the effectiveness of healthcare professionals, rather than replacing them.”
The doctor will still see you now
Dr Mark Murphy, GP, and chair of Communications with the Irish College of General Practitioners, responds:
“It is unlikely that AI will make a meaningful difference in the GP setting, given the significant human factors at play in a consultation.
“There is a requirement for the GP to conduct face-to-face consultation to develop a rapport, to physically examine a patient and read nonverbal cues.”
“AI systems cannot get rid of the complex uncertainty and greyness at the heart of the undifferentiated presentations to General Practice.
“However, AI and machine learning will help with the handling of information in the healthcare system, and may be able to assist with complicated ‘black and white’ diagnostic process, such as imaging or to make sense of the complex genomic factors with rare-disease treatment.”
The Allen Telescope Array in Hat Creek California is set up to search for signs of extra-terrestrial intelligence (Image source: Sky & Telescope)
For millions of years – as long as humans have existed and gazed upwards – people will have questioned are we alone in the Universe? Yet, it is only in the past 60 years or so, with rapid technological advances, that it has become possible to make serious attempts to answer that age-old question.
Listen to interview with Myles Dungan on The History Show, RTE Radio 1 (broadcast 2/04/17)
The ancient Greeks, the foundation stone upon which much of our western way of life today has been built, were the first, in the west at least, to consider the possibility that the Universe was infinite and that it contained an infinite number of civilisations.
The arrival in the 16th century of the Copernican model of our Solar System, where the Earth revolved around the Sun, impacted on our thoughts of ET life too.
This radical science, which place the Sun at the centre of the Solar System, not the Earth, implied that our planet was not perhaps as important as we had thought.
If Earth was just one planet of several orbiting the Sun, and not at the centre of everything, then why could there not be life, like us, on other similar planets?
This, of course, caused complications for some established religions, as if there was life, like us, on other planets, then had Jesus come down to save them too?
There things stood, with lots of questions, but no ability to answer them, for several centuries until the second half of the twentieth century.
In the 1950s, at the height of Cold War paranoia, the number of reported sightings of UFOs increased dramatically across the United States.
In 1959, two young scientists at Cornell University decided to try and take a serious scientific look at how mankind might try to tune in to alien communications.
The paper appeared in Nature, one of the world’s top scientific journals, and it was called ‘Searching for Interstellar Communications’.
This paper changed everything because it established the scientific principles by which scientists might try to find, and listen in to alien communications, if they existed.
The authors, Guiseppe Cocconi and Philip Morrison were both physicists based at Cornell University in upstate New York. They said that the possibility of extra-terrestrial ‘intelligent’ life couldn’t be determined, or ruled in or out. However, given that mankind evolved it was likely that other intelligent creatures evolved too, on planets near a Sun. Some of these civilisations might, the authors said, be more advanced than our own and may want to contact us and other intelligent beings that resided on planets – like them – close to a warm Star.
The two physicists considered how intelligent extra-terrestrials might make contact with us, and decided that electromagnetic waves, which travel at the speed of light and are not easily knocked off course, would be the most logical way to transmit a message.
Furthermore, they decided that the most likely frequency the aliens would broadcast on would be 1,420 megahertz as that is the ‘emission frequency’ of hydrogen, the most abundant element in the Universe. This is the frequency of the radio wave emissions given off when an atom in an element, in this case hydrogen, is given off as the element moves from a high energy atomic configuration into a lower energy configuration.
The aliens, the logic went, would chose this frequency because they knew other intelligent beings would also understand its importance and tune in accordingly.
The paper inspired a now-famous astronomer called Frank Drake to perform the first scientific experiment to search for extra-terrestrial intelligence. That was 1960.
Drake, is still alive, aged 86, and an active astronomer, and considered the Father of SETI the Search for Extra-terrestrial life, and the SETI Institute in the USA.
Drake pointed a radio telescope at two ‘nearby’ stars called Tau Ceti and Epsilon Eridani to see whether there was anything being broadcast from planets orbiting these Sun-like bodies in the hydrogen emission frequency from that location. There wasn’t.
Today, the SETI Institute, based in Northern California, has access to a $30 million array of telescopes, funded by Paul Allen, the co-founder of Microsoft. It has a permanent staff of scientists, and is supported by donations and computer power by SETI enthusiasts all over the world. It is not reliant on US taxpayers’ support.
Drake, apart from founding SETI, is also famous for producing something called the Drake equation along with Carl Sagan, to predict how many civilisations there might be in the Universe, based on known parameters.
In 1961, when the Drake equations was first produced, it predicted there was from 1,000 to one billion such civilisations, and the range was down to the fact that the parameters were nebulous.
The Drake equation has become more accurate over the years, based on better knowledge of parameters such as how often Sun-like Stars form, and how many of these stars have planets. But we still don’t know how precisely life begins, even on Earth, or what fraction of life will evolve to become intelligent.
The implications of the Cocconi and Morrison article took time to be absorbed by the mainstream scientific community, but eventually, in 1971, NASA got on board by setting up Project Cyclops at NASA. This was the first formalised, publicly-funded research project into searching for ET life.
The funding wasn’t enough for scientists at Cyclops to do a great deal, but even at its low level of funding, it soon came under political attack.
In 1978, Senator William Proxmire bestowed one of his infamous ‘golden fleece’ awards on the SETI programme, deriding it as a waste of taxpayers’ money.
In 1981, a Proxmire amendment killed off SETI funding for the following year with Proxmire saying that it was a silly search for aliens unlikely to produce results.
In 1993, NASA got back into SETI work, this time with the High Resolution Microwave Survey Targeted Search programme. But, again, this project too came under political attack and lost is operational funding just one year after it began.
It wasn’t just politicians who were critical of SETI work, scientists were critical too, who supported the view outlined by the late nuclear physicist Enrico Fermi.
Fermi, who had died in 1954, did not accept the view (held by many at SETI) that the Universe was teeming with life, based on its size, and number of planets near Stars.
Fermi said that if the SETI people were to be believed, and the Universe was teeming The Earth was 4.5 billion years old, Fermi had said, and there was no evidence of extra-terrestrial life visiting here in all that time.
He had asked the question if there is so much life out there, ‘where is everybody’. It was a simple, yet, devastating riposte to the Drake equation.
Fermi had come up with his idea in 1950, but many scientists still point to it.
Yet, Fermi was not alive when two things happened, both in the mid-1970s, which are the best pieces of evidence for the existence of extra-terrestrial life.
The first story concerns an experiment that took place when the Viking landers landed on Mars in 1976. Some readers will remember the amazing colour pictures of the surface of Mars shown on TV at the time.
Viking 1 and Viking 2 were NASA space probes sent to Mars for the sole purpose of determining whether life existed on the planet.
One of three experiments on board worked was set up to see if the soil contained microbes. If it did, the life forms in the Martian soil would ingest and metabolise the nutrients and release either radioactive carbon dioxide or methane gas which could be measured by a radiation detector on the space probe.
The minute the nutrients were mixed with the soil sample there was a huge reaction with something like 10,000 counts of radioactive molecules being produced. This was a huge spike because the radiation background on Mars was 50 or 60 counts.
The experiment was, thus, positive for life, but NASA did not announce it had found life because the other two experiments on board which were negative for life.
The other piece of ‘evidence’ that is put forward concerns what is called the ‘Wow signal’, which was received by the Big Ear Telescope on 15th August 1977. The telescope was scanning for signals coming in from potential ET intelligent beings.
This was a strong narrowband signal which appeared to come from the constellation Sagittarius, and was in the 1,420 MHz frequency band. It was precisely the sort of signal that the SETI researchers were looking for as being of ET origin.
Jerry Ehman, a volunteer astronomer working with SETI spotted this massive, powerful, narrow band Wo signal on the paper readouts he was going through while sitting at his kitchen table a few days later.
Ehman was stunned by the signal and was so taken back by it that he wrote the comment ‘Wow’ in the paper margins, hence the name Wow signal.
The signal lasted 72 seconds, then the Earth rotated, the signal dropped out of view of the telescope, and when the same region of sky came into view again, it was gone.
The signal helped inspire the film Contact (1997) starring Jodie Foster.
Jerry Ehman went through every conceivable possible earthbound source for the signal, such as nearby military and civilian communications, but nothing could explain it. It remains the strongest candidate ever detected for an alien radio transmission.
The biggest thing to happen in recent years was the announcement in 2015 of $100 million privately funded search for ET life over 10 years, or about 10 million per year. This is big even compared to the annual funding for SETI of about 2 million dollars per annum. The Breakthrough Listen and Breakthrough Message initiatives are supported by the Russian internet investor and physicist Yuri Milner and supporter by big names like Stephen Hawking, Martin Rees and Frank Drake.
This will survey the one million stars in the Milky Way closest to Earth, as well as the 100 closest galaxies for signs of intelligent life beyond Earth, in the form of artificial radio or optical transmissions that cannot be explained by natural phenomenon.
The advance of technology and our ability to scan more areas of our vast galaxy and Universe mean that people like Seth Shostak, an astronomer at SETI believes that we will have discovered ET life, intelligent or not, inside the next 20 years.
Listen below to the story of Jocelyn Bell Burnell as part of the Irish Scientists series which was broadcast on East Coast FM in December 2016
Jocelyn Bell Burnell from Lurgan Co. Armagh discovered a new type of star, called pulsars in the 1960s
Jocelyn Bell Burnell, pictured on the right, who grew up and was educated in Lurgan, discovered pulsars, a new family of incredibly compact tiny stars back in 1968. It was a discovery that many astronomers believed merited a Nobel Prize. The Nobel Committee agreed and a Prize was duly awarded for the discovery in 1974. The problem was the Prize went not to Jocelyn, but to her supervisor.
At the time she made the discovery, 67-year-old Jocelyn (who is still an active researcher) was a 24-year old post-graduate student. She was also a woman. Those things still mattered in science in the 1960s, and might have…
The first photographs ever taken of the aftermath of an earthquake were taken of the Great Neopolitan Quake of 1857, which destroyed the village of Pertosa, pictured here, and many other towns and villages in southern Italy. The pictures were taken by a Frenchman called Grellier, and commissioned by Irish scientist and Dubliner Robert Mallet who was the first to determine what caused earthquakes such as this one [Credit: Dublin Institute for Advanced Studies].
Listen here to the story of Robert Mallet
First broadcast on East Coast FM in December 2017 as part of the Irish Scientists series produced by Red Hare Media.
The science of seismology, which studies the power and energy unleashed by earthquakes, began life on a south Dublin beach in 1849 with an ingenious experiment carried out by one of Ireland’s greatest scientists. That scientist was Robert Mallett – a Dubliner widely recognized as the ‘father…
The Immortal life of Henrietta Lacks based on the book written by Rebecca Skloot in 2010 will appear on our cinema screens this year, with Oprah Winfrey in the role of Henrietta.
But, who was Henrietta Lacks, what was her story, why is her life described as “immortal” and how has it influenced the lives of millions of people around the world since her death in 1951?
Henrietta Lacks, pictured, died from cervical cancer in 1951, aged 31. Cancer cells removed from her body without her knowledge or permission were used to produce the polio vaccine Credit (Henrietta Lacks Foundation).
Henrietta Lacks was a poor black woman from the tobacco fields of the state of Virginia, USA, part of the old South.
She has made a huge contribution to mankind, because of the cells she unwittingly gave to the world, so called ‘HeLa cells’ which were taken from the cancer that killed her in 1951 and grown in labs around the world to combat disease, and help scientists develop techniques like cloning and I.V.F.
The cells have been used to produce a vaccine for polio, leading to its eradication in the USA and most parts of the world, but they have also been used to produce commercial revenue. Henrietta didn’t provide ‘consent’ for her cells to be used in this way, but in 1951, consent was not a requirement for doctors to remove cells or tissues from patients for research purposes.
Henrietta was born with the name Loretta Pleasant on the 1st August 1920 in Roanoke, the biggest town, but still a small-ish city, in southwestern Virginia. At some stage, for reasons not clear, she became Henrietta, a name that was shortened to ‘Hennie’ after the death of her mother.
Henrietta’s mother died when Henrietta was 4 and ‘Hennie’ and her nine siblings were sent to live with various aunts and uncles and cousins in the little farming town of Clover, Virginia.
Hennie ended up with her grandfather, who was also trying to raise one of Hennie’s first cousins – David. They lived in a two-story cabin built of hand-carved logs, and held together by pegs that was once the slave quarters of their ancestors.
In 1924 rural Virginia, black people were no longer slaves, but their social, economic and living circumstances, even the actual buildings that that lived in, hadn’t changed much since the Emancipation Proclamation was issued by President Abraham Lincoln on 1st January 1863. This executive order changed the federal legal status of some 3 million black slaves trapped in the Confederate south from ‘slave’ to ‘free’.
The former slave quarters that Hennie found herself living in with her grandfather and cousin David looked over the family cemetery where Hennie’s ancestors, who were black, but some of whom were also white, including one of her great grandfathers, were buried.
All around the slave house, or ‘home house’ as its residents called it were hundreds of acres of tobacco fields. The area was, and is known as Lacks Town, as many of the people living in and around the tobacco fields were ‘kin’ to Henrietta.
Hennie had honey coloured skin, a round face, and an attractive, welcoming smile. After a time, according to cousins accounts, Hennie and David, who was called ‘Day’ became an item, even though they had been raised like a brother and sister.
Children followed. Lawrence was born in 1935, and Elsie, who was “deaf and dumb”, and ended up later in a home for the Negro Insane, was born in 1939.
In 1941, Hennie and Day got married, and made plans to get out of Clover, forget the tough life of tobacco farming, and join the many black people that were heading for Baltimore and Washington DC to get jobs in the booming wartime shipyards and steel mills.
Hennie, according to accounts, settled into her new life as housewife in a brick city apartment, but she missed the country and would often grab her kids, and pile them onto a bus for a trip back to Clover.
It seems Hennie loved being a mother, and more children came with Sonny born in 1947, and Deborah in 1949. Their fifth child, Joe, was born in 1950.
A few months after Joe was born Hennie shared a secret with her cousin Sadie, Sadie later recalled. She started bleeding, even though it was not her time of the month, and one morning when she was taking a bath she felt a lump.
Hennie decided to attend the outpatient centre at Johns Hopkins Hospital in Baltimore – a renowned centre for medical excellence in February 1951 and the gynaecologist on duty when Henrietta came in was Dr Howard Jones. Dr Jones examined Henrietta and found something remarkable: a glistening, smooth growth that resembled what he called “purple Jell-O” (jelly).
The growth was about the size of a US quarter, and positioned at the lower right of Henrietta’s cervix. The growth bled easily when it was touched.
Dr Jones thought it might be an infection and tested for syphilis, but the results came back negative. He ordered a biopsy and got the diagnosis: sadly for Hennie, it was cancer.
Henrietta came back for treatment 8 days later, and another doctor took another slice off her tumour. Henrietta wasn’t told about this, but, at the time, that was normal medical practice.
Capsules of radium were placed around her cervix to try and kill the cancer cells and she was released from hospital and went home. Henrietta didn’t tell anyone about her illness, and continued with home life as normal.
She came back regularly for treatment, but the cancer cells were growing faster than radium could kill them and it was difficult for her now to hide her pain.
She was admitted to hospital for the last time in August 1951, for what would be the last time. A few months later, on 4th October 1951 Henrietta died, aged 31, with an autopsy showing that she had cancerous lumps in her chest cavity, lungs, liver, kidney and right through her bladder. The cancer had been relentless, and grew and spread at a pace that proved uncontrollable.
Henrietta was buried in an unmarked grave her the ‘home house’ in Clover. Her children remember it as a day when the rain poured from the sky as though heaven were weeping for ‘Hennie’.
The death of Hennie was devastating to Henrietta’s family, her husband Day and their five children. This is apparent, as even all these years later they get upset talking about her death, it seems.
Her death was something of a taboo subject, and no-one was comfortable talking about it, as it affected them so deeply.
Day tried to keep the show on the road by working shifts at the shipyard, while minding his three youngest children. Elsie was now in a home for the Negro Insane and family visits were not as frequent was when Henrietta was alive, as she visited Elsie regularly. Lawrence, the eldest left to join the Army.
Two relatives moved in to live with Day and the three children, one of which was described as ‘evil’ and life became brutal and horrible, with the children being beaten for no reason and having little food to eat.
As the children grew older, they – understandably – wanted to get away as much as possible from the nightmare house in Baltimore and they regularly returned to Clover to work on tobacco, as their mum had done, keeping their abuse a secret.
Elsie died in 1955, aged just 16, and it appears that sadly she had been abused, and she may even have had holes drilled in her head for some kind of human experimentation.
When Henrietta’s children had their own children, it seems that – perhaps sensing something from their parents – they too avoided the subject of their grandmother, how she lived and how she died.
Henrietta’s family knew nothing until the early 1970s when family members received phone calls from researchers asked for them to donate blood samples. The researchers said that they wanted to find out more about their mother’s genetic make-up.
Naturally, the family members wanted to know why they were interested in this, now, many years after Henrietta’s death. They were then told – and this must have been utterly shocking to them – that part of their mother, some of her cells, were still alive and growing now, more than 20 years after her death.
The Lacks family finally learned that tissue from their mother’s second biopsy in 1951 had been given to Johns Hopkins researcher Dr George Gey, who was searching for a cure to cancer, and had, towards this end, but trying – unsuccessfully – to grow human cells outside the body, so that they could be closed studied in the lab.
Dr Gey’s lab technicians got Henrietta’s cells, but – by now programmed for failure – expected them to do what many previous cell samples had done – live for a short time, a few days tops, then die. Yet, what happened astonished them. Henrietta’s cells multiplied in petri dishes, uncontrollably spreading and piling up on one another.
On the very same day that Henrietta died, 4th October 1951, Gey was appearing on a TV show called ‘Cancer Can be Conquered.” On the show he held a bottle close to the camera, and in it he said was the first human cell line ever grown. This was Henrietta’s legacy.
The cells were called “HeLa cells” by Gey, to acknowledge the first two letters of Henrietta Lacks’ first and last names. He then gave samples out to other researchers around the USA. The idea was that HeLa cells would work enough like normal cells so that doctors could test, probe and unlock their secrets and weaknesses in the lab. This new knowledge, it was hoped, would lead to a cure for cancer.
The biggest impact, without doubt, that HeLa cells have, so far at least, made on the world is by helping Jonas Salk create a vaccine which has almost eradicated – worldwide – what was a crippling disease affecting children.
Salk infected HeLa cells with the poliovirus – something that could easily be achieved – and studied how they reacted. After a number of years of work, in 1955, he had created a working vaccine.
This received huge attention because polio mainly affects children under 5 years of age, so young children had been dying and the name polio was a terrifying one until Salk came along.
Polio is highly infectious. It kills when some infected children become paralysed and their breathing muscles immobilised. It is still a threat in certain parts of the world, according to the WHO, but the number of cases, worldwide have decreased from 350,000 cases in 1988 to just 74 reported cases in 2015.
It is estimated that the polio vaccine, and, thus, HeLa cells that helped created it, have saved the lives of one million people, many of them young children, around the world since 1955, who would otherwise have died of polio.
In 1952, just three years beforehand, there was a polio outbreak in the USA which killed 3,145 people, including 1,873 children. At that rate, some 192,000 Americans would have died if the polio vaccine had not been available there from 1955.
The HeLA cells were ideal for developing a polio vaccine because they could be easily infected by poliomyelitis, which caused infected cells to die. However, a large volume of HeLa cells were needed to test Salk’s vaccine, and this led to the mass production of HeLa cells from 1953 in a cell culture ‘factory’ at Tuskegee University.
Controversially, however, companies also used HeLa cells to test cosmetics, and to measure the effects of radiation on human cells. They were used to test how human cells responded to other viruses, and were used in a number of cancer trials.
HeLa were the first ‘cell lines’, they stored well, were robust and could be sent out to laboratories all over the world. They replicate very fast, which is useful, but can also cause problems for scientists in terms of contamination of the lab.
HeLa cells have been used to study all kinds of viruses, and helped in the creation of a vaccine to HPV, the human papillomavirus, as well as to act as a testbed for new medications for cancer and Parkinson’s disease. They have also been used to test how certain products, such as cosmetics, affect human cells.
Because some HeLa cells behave differently to others, it has been possible for scientists to isolate a specific cell type, multiple it, and start a new cell line. This method of isolating a cell and keeping it alive is the basic technique behind I.V.F. which is so much part of our world today.
One discovery from HeLa cells has big potential in the fight against cancer. It was found that HeLa cells used an enzyme to repair their DNA and keep functioning when other cells would have died. Anti cancer trials against this enzyme are currently ongoing.
There are some who would say that the importance of HeLa cells in saving lives has been overstated. For example, saving one million lives with the polio vaccine, is small potatoes compared to, say the Measles vaccination, which has saved about 17 million lives since 2000.
Henrietta’s family were angry when they finally heard the full story of the HeLa cells. They felt that Johns Hopkins Hospital had removed Henrietta’s cells without permission. The hospital had done that, they didn’t deny it, and neither did they deny that they hadn’t asked permission. Permission to do this wasn’t required back in 1951.
The Lacks family were also confused by all the scientific jargon that started to come their way. I think they their initial reaction was that their mother, and themselves had been exploited by researchers. For instance, they said that they gave blood to the researchers when asked, but the researchers did not bother to follow up with them when results came out or to explain results.
None of the children have developed their mother’s aggressive cancer, so Henrietta left no deadly legacy to her children.
There was a financial issue also, as far as the Lacks family were concerned because biomedical companies in the decades since their mother’s death had been mass producing HeLa cells, like a license to print money, and sending them out all over the world.
Fortunes were being made on the back of their mother’s cells, while they themselves, could even afford health insurance.
They were also apparently hurt that so many people, researchers, scientists and doctors, appeared to know so much about their mother, and that they, her children, knew very little.
Their father Day died in 2002 (41 years after his wife Henrietta) but the family only managed recently to pool together money for a headstone for his grave.
Johns Hopkins have honoured the contribution of Henrietta, and others like her, to their research, but they remain sensitive to criticism of their role in the Lacks’ story. They made the point that the hospital as it was in 1951 can’t be judged by today’s standards, and that patient consent, now a basic standard, wasn’t even considered in 1951.
The HeLa cells, Johns Hopkins state, were given away by their researcher Dr Gey, acting on his own and the hospital never patented the HeLa cells or sold them to make money. Dr Gey, they add was acting with good intent as he passed the cells on in the hope researchers could develop a module from which scientists could learn more about human cell function (and by corally, cancer cell function).
HeLa cells have today multiplied to the point where they weigh some 20 tonnes, all together, while, according to the US Patent and Trademark Office there are close to 11,000 patents that involve HeLa cells. The cells are so widely available that they can be ordered for delivery on the Internet.
The words on Henrietta’s gravestone, composed by her grandchildren reads:
“In loving memory of a phenomenal woman, wife and mother who touched the lives of many. Here lies Henrietta Lacks (HeLa). Her immortal cells will continue to help mankind forever.”